Can the GeForce RTX 4090 (used) run Mistral NeMo 12B Instruct (2407)?
Fits comfortably at Q4_K_M.
Mistral NeMo 12B Instruct (2407) is 12.2B parameters. At Q4_K_M the weights are about 6.8 GiB; with the 1.5 GiB runtime reserve that is 8.3 GiB against the card's 24GB, leaving about 15.7 GiB for context.
All three quants
24GB card| Quant | Weights | With reserve | Verdict | Headroom |
|---|---|---|---|---|
| Q4_K_Mthe everyday quant | 6.8 GiB | 8.3 GiB | Fits comfortably | 15.7 GiB |
| Q8_0near-lossless | 12.0 GiB | 13.5 GiB | Fits comfortably | 10.5 GiB |
| FP16full weights | 22.7 GiB | 24.2 GiB | Only with CPU offload | short 0.2 GiB |
Verdict rules: fits comfortably when weights plus reserve sit within 85% of VRAM; tight when they fit with little left for context; CPU offload when they exceed VRAM by up to 2x (runs, slowly, with layers in system RAM); no beyond that. The KV cache per token depends on the model's architecture and is not modelled here.
Good match. Get the card.
The GeForce RTX 4090 (used) clears Mistral NeMo 12B Instruct (2407) at Q4_K_M and at Q8_0. Live listings below; this page was rebuilt 2026-08-23.
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About the model
Mistral NeMo 12B Instruct (2407) by Mistral AI: 131,072-token native context, text, released 2024 under the Apache-2.0. Model card → · Hosted pricing on PicksByModel →