Can the Radeon RX 9070 run Mixtral 8x22B Instruct v0.1?
Does not fit at Q4_K_M.
Mixtral 8x22B Instruct v0.1 is 141B parameters (MoE; all experts resident). At Q4_K_M the weights are about 78.8 GiB; with the 1.5 GiB runtime reserve that is 80.3 GiB against the card's 16GB, about 64.3 GiB more than the card has.
All three quants
16GB card| Quant | Weights | With reserve | Verdict | Headroom |
|---|---|---|---|---|
| Q4_K_Mthe everyday quant | 78.8 GiB | 80.3 GiB | Does not fit | short 64.3 GiB |
| Q8_0near-lossless | 139.2 GiB | 140.7 GiB | Does not fit | short 124.7 GiB |
| FP16full weights | 262.6 GiB | 264.1 GiB | Does not fit | short 248.1 GiB |
Verdict rules: fits comfortably when weights plus reserve sit within 85% of VRAM; tight when they fit with little left for context; CPU offload when they exceed VRAM by up to 2x (runs, slowly, with layers in system RAM); no beyond that. The KV cache per token depends on the model's architecture and is not modelled here.
The numbers for this pairing
At Q4_K_M the weights take about 78.8 GiB, so with the 1.5 GiB runtime reserve it needs 80.3 GB: 64.3 GB more than the card's 16 GB.
No version of it fits entirely in this card's memory, so it would lean on system RAM and run far slower.
It is a mixture-of-experts model: about 39B of its 141B parameters work on each token, which helps speed, but all of them still have to fit in memory.
At about $570, this card costs roughly $36 per GB of VRAM.
Running it at its full 220 W board power for 4 hours a day would use about 26 kWh a month, about $4.86 at the US average residential rate of 18.4 cents per kWh (2026-05); real use sits below that ceiling.
Prices are the lowest current listings our tracker saw on Oct 7, 2026, since averages include premium variants; launch prices are marked where we have no listing.
Not this card. These fit it comfortably at Q4.
Nothing in the consumer catalog fits Mixtral 8x22B Instruct v0.1 at Q4 on a single card; this is multi-GPU or datacenter territory, or a job for hosted inference (see PicksByModel for per-token pricing).
What the Radeon RX 9070 does run well → · Mixtral 8x22B Instruct v0.1 on every card →
About the model
Mixtral 8x22B Instruct v0.1 by Mistral AI: 65,536-token native context, text, released 2024 under the Apache-2.0. Model card → · Hosted pricing on PicksByModel →