Can the GeForce RTX 5090 run Mixtral 8x7B Instruct v0.1?
Fits, tight on context at Q4_K_M.
Mixtral 8x7B Instruct v0.1 is 46.7B parameters (MoE; all experts resident). At Q4_K_M the weights are about 26.1 GiB; with the 1.5 GiB runtime reserve that is 27.6 GiB against the card's 32GB, leaving about 4.4 GiB for context.
All three quants
32GB card| Quant | Weights | With reserve | Verdict | Headroom |
|---|---|---|---|---|
| Q4_K_Mthe everyday quant | 26.1 GiB | 27.6 GiB | Fits, tight on context | 4.4 GiB |
| Q8_0near-lossless | 46.1 GiB | 47.6 GiB | Only with CPU offload | short 15.6 GiB |
| FP16full weights | 87.0 GiB | 88.5 GiB | Does not fit | short 56.5 GiB |
Verdict rules: fits comfortably when weights plus reserve sit within 85% of VRAM; tight when they fit with little left for context; CPU offload when they exceed VRAM by up to 2x (runs, slowly, with layers in system RAM); no beyond that. The KV cache per token depends on the model's architecture and is not modelled here.
The numbers for this pairing
At Q4_K_M the weights take about 26.1 GiB; with the 1.5 GiB we set aside for the runtime that is 27.6 of the card's 32 GB, leaving about 4.4 GB for the context cache.
It is a mixture-of-experts model: about 12.9B of its 46.7B parameters work on each token, which helps speed, but all of them still have to fit in memory.
At about $6,500, this card costs roughly $203 per GB of VRAM.
Running it at its full 575 W board power for 4 hours a day would use about 69 kWh a month, about $12.70 at the US average residential rate of 18.4 cents per kWh (2026-05); real use sits below that ceiling.
Prices are the lowest current listings our tracker saw on Oct 7, 2026, since averages include premium variants; launch prices are marked where we have no listing.
Good match. Get the card.
The GeForce RTX 5090 clears Mixtral 8x7B Instruct v0.1 at Q4_K_M. Live listings below; this page was rebuilt 2026-10-07.
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About the model
Mixtral 8x7B Instruct v0.1 by Mistral AI: 32,768-token native context, text, released 2023 under the Apache-2.0. Model card →