picksbycard
August 23, 2026No. 113
GeForce RTX 5060 · 8GB GDDR7

Can the GeForce RTX 5060 run Mistral NeMo 12B Instruct (2407)?

Only with CPU offload at Q4_K_M.

Mistral NeMo 12B Instruct (2407) is 12.2B parameters. At Q4_K_M the weights are about 6.8 GiB; with the 1.5 GiB runtime reserve that is 8.3 GiB against the card's 8GB, about 0.3 GiB more than the card has.

All three quants

8GB card
QuantWeightsWith reserveVerdictHeadroom
Q4_K_Mthe everyday quant6.8 GiB8.3 GiBOnly with CPU offloadshort 0.3 GiB
Q8_0near-lossless12.0 GiB13.5 GiBOnly with CPU offloadshort 5.5 GiB
FP16full weights22.7 GiB24.2 GiBDoes not fitshort 16.2 GiB

Verdict rules: fits comfortably when weights plus reserve sit within 85% of VRAM; tight when they fit with little left for context; CPU offload when they exceed VRAM by up to 2x (runs, slowly, with layers in system RAM); no beyond that. The KV cache per token depends on the model's architecture and is not modelled here.

Not this card. These fit it comfortably at Q4.

What the GeForce RTX 5060 does run well → · Mistral NeMo 12B Instruct (2407) on every card →

About the model

Mistral NeMo 12B Instruct (2407) by Mistral AI: 131,072-token native context, text, released 2024 under the Apache-2.0. Model card → · Hosted pricing on PicksByModel →

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